157716-52-4

培美曲塞

157716-52-4

编号ABP000409 化学名称培美曲塞 英文名称 Perifosine/D21266 /D-21266 MDL: MFCD00927554 分子式C25H52NO4P 分子量461.663 纯度 99%

化学名称 : 培美曲塞

CAS : 157716-52-4

英文名称: Perifosine/D21266 /D-21266

英文同义词: PERIFOSINE

溶解度:Soluble in water at 10mg/ml

储存条件:-20C 2 years

生物活性

Alkylphospholipids are a class of antineoplastic compounds that display potent antiproliferative activity in several in vitro and in vivo human tumor models. Perifosine(D 21266 ) is an alkylphospholipid that induces apoptotic cell death in a variety of tumor cell lines. Apoptosis is induced in a time- and dose-dependent manner in U937 and Jurkat T human leukemia cell lines but not in normal vascular endothelial cells. Perifosine(D 21266 ) causes inhibition of PC-3 prostate carcinoma cell growth (growth inhibition (GI50) = 5µM at 24h) and is associated with rapidly decreased Akt activation. In addition, perifosine induces p21WAF1 expression in squamous carcinoma cells through a p53-independent pathway, leading to loss in cyclin-dependent kinase activity and cell cycle arrest.

参考文献

1 Ruiter, G.A., Zerp, S.F., Bartelink, H., et al. Alkyl-lysophospholipids activate the SAPK/JNK pathway and enhance radiation-induced apoptosis. Cancer Res 59 2457-2463 (1999).

2 Kondapaka, S.B., Singh, S.S., Dasmahapatra, G.P., et al. Perifosine, a novel alkylphospholipid, inhibits protein kinase B activation. Molecular Cancer Therapeutics 2 1093-1103 (2003).

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