153259-65-5

溶解度:DMSO

储存条件:at -20℃ 2 years

生物活性

Cilomilast(SB-207499) is among the first of a new generation of PDE4 inhibitors (Ki ≈100 nM). Cilomilast(SB-207499) inhibits HPDE4 and LPDE4 catalytic activity with equal potency (Ki ≈100 nM). SB-207499 and rolipram are equipotent against LPDE4, but Cilomilast(SB-207499) is 100-fold less potent against HPDE4. This profile suggests that Cilomilast(SB-207499) retain the anti-inflammatory activity of rolipram yet have a decreased tendency to produce side effects.

参考文献

[1] MARY S. BARNETTE et al. JPET.1998,284(1):420-426