化学名称 : 非布索坦
CAS : 144060-53-7
英文名称: Febuxostat(Uloric) /
英文同义词: FEBUXOSTAT
溶解度:Unknown
储存条件:at -20℃ 2 years
生物活性
Febuxostat is a non-purine selective XAO inhibitor with IC50 of 114 -210 nM. It works by non-competitively blocking the channel leading to the active site on xanthine oxidase. [1] Xanthine oxidase is needed to successively oxidize both hypoxanthine and xanthine to uric acid. Hence, febuxostat inhibits xanthine oxidase, therefore reducing production of uric acid.
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