144060-53-7

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非布索坦

144060-53-7

编号ABP000399 化学名称非布索坦 英文名称 Febuxostat(Uloric) / MDL: MFCD00871598 分子式C16H16N2O3S 分子量316.379 纯度 >99%

化学名称 : 非布索坦

CAS : 144060-53-7

英文名称: Febuxostat(Uloric) /

英文同义词: FEBUXOSTAT

溶解度:Unknown

储存条件:at -20℃ 2 years

生物活性

Febuxostat is a non-purine selective XAO inhibitor with IC50 of 114 -210 nM. It works by non-competitively blocking the channel leading to the active site on xanthine oxidase. [1] Xanthine oxidase is needed to successively oxidize both hypoxanthine and xanthine to uric acid. Hence, febuxostat inhibits xanthine oxidase, therefore reducing production of uric acid.

参考文献

[1] http://en.wikipedia.org/wiki/Febuxostat

[2] Gaffo AL et al. Core Evid. 2010 Jun 15;4:25-36

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