![N-[3-[(4AS,7AS)-2-氨基-4A,5-二氢-4H-呋喃并[3,4-D][1,3]噻嗪-7A(7H)-基]-4-氟苯基]-5-氟-2-吡啶甲酰胺](http://stcdn.activebiopharma.com/active/ABP000957.png)
1262036-50-9
编号ABP000957
化学名称N-[3-[(4AS,7AS)-2-氨基-4A,5-二氢-4H-呋喃并[3,4-D][1,3]噻嗪-7A(7H)-基]-4-氟苯基]-5-氟-2-吡啶甲酰胺
英文名称 LY2886721/LY-2886721/
MDL: MFCD21609263
分子式C18H17FN4O2S
分子量372.422
纯度 >98%
化学名称 : N-[3-[(4AS,7AS)-2-氨基-4A,5-二氢-4H-呋喃并[3,4-D][1,3]噻嗪-7A(7H)-基]-4-氟苯基]-5-氟-2-吡啶甲酰胺
CAS : 1262036-50-9
英文名称: LY2886721/LY-2886721/
英文同义词: LY2886721
溶解度:Unknown
储存条件:at -20℃ 2 years
生物活性
AZD8330 (RRY-424704，ARRY-704) is an orally active, selective MEK inhibitor with an IC50 of 7 nM. AZD8330 (RRY-424704，ARRY-704) has potential antineoplastic activity. AZD8330 (RRY-424704，ARRY-704) specifically inhibits mitogen- activated protein kinase kinase 1 (MEK or MAP/ERK kinase1), resulting in inhibition of growth factor-mediated cell signaling and tumor cell proliferation. MEK is a key component of the RAS/RAF/MEK/ERK signaling pathway that regulates cell growth. Constitutive activation of this pathway has been implicated in many cancers. [1][2]
参考文献
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