1196109-52-0

N-3-吡啶基-4-[[3-[[5-(三氟甲基)-2-吡啶基]氧基]苯基]甲基]-1-哌啶甲酰胺

1196109-52-0

编号ABP000926 化学名称N-3-吡啶基-4-[[3-[[5-(三氟甲基)-2-吡啶基]氧基]苯基]甲基]-1-哌啶甲酰胺 英文名称 PF3845 分子式C24H23F3N4O2 分子量456.4602 纯度 >99 %

化学名称 : N-3-吡啶基-4-[[3-[[5-(三氟甲基)-2-吡啶基]氧基]苯基]甲基]-1-哌啶甲酰胺

CAS : 1196109-52-0

英文名称: PF3845

英文同义词: N-(Pyridin-3-yl)-4-(3-((5-(trifluoromethyl)pyridin-2-yl)oxy)benzyl)piperidine-1-carboxamide

溶解度:DMSO

储存条件:at -20℃ 2 years

生物活性

BMS777607 is a Small-Molecule Met Kinase Inhibitor with an IC50 of < 0.1 μM. Its treatment had little effect on tumor cell growth but inhibited cell scattering activated by exogenous HGF, with almost complete inhibition at 0.5 μmol/L in PC-3 and DU145 cells. This agent also suppressed HGF-stimulated cell migration and invasion in a dose-dependent fashion (IC50 < 0.1 μmol/L) in both cell lines. Mechanistically, nanomolar doses of BMS 777607 potently blocked HGF-stimulated c-Met autophosphorylation and downstream activation of Akt and extracellular signal-regulated kinase. In addition, both wortmannin and U0126, but not dasatinib, attenuated cell scattering and migration induced by HGF, suggesting the involvement of the phosphoinositide 3-kinase and mitogen-activated protein kinase pathways, but not of Src or focal adhesion kinase, in HGF-mediated motogenic effects.

参考文献

[1] Dai Y et al. Mol Cancer Ther. 2010 Jun;9(6):1554-61.

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