1187594-09-7

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巴瑞替尼

1187594-09-7

编号ABP001023 化学名称巴瑞替尼 英文名称 INCB 028050 分子式C16H17N7O2S 分子量371.417 纯度 98%

化学名称 : 巴瑞替尼

CAS : 1187594-09-7

英文名称: INCB 028050

英文同义词: 2-(3-(4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl)-1-(ethylsulfonyl)azetidin-3-yl)acetonitrile

生物活性

Potent, irreversible human epithelial growth factor receptor 2 (ErbB2) inhibitor (IC50 = 6 nM) that displays > 4000-fold selectivity over EGFR, FGFR, PDGFR, JAK1 and Src. Exhibits potent antiproliferative effects in ErbB2-overexpressing cancer cell lines (IC50 = 5 nM in BT474 breast cancer cells) and significantly inhibits bladder, breast and prostate cancer xenograft growth in vivo.
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