1174046-72-0

BMS794833/BMS 794833

1174046-72-0

编号ABP000884 化学名称BMS794833/BMS 794833 英文名称 BMS794833/BMS 794833 MDL: MFCD18206786 分子式C23H15ClF2N4O3 分子量468.845 纯度 >99%

化学名称 : BMS794833/BMS 794833

CAS : 1174046-72-0

英文名称: BMS794833/BMS 794833

英文同义词: BMS 794833

生物活性

GSK1363089 (XL880)is an orally bioavailable,small molecule MET/VEGFR2 inhibitor with potential antineoplastic activity. This compound binds to and selectively inhibits HGF receptor c-MET(IC50 of 0.4 nM)and VEGFR2, which may result in the inhibition of tumor angiogenesis, tumor cell proliferation and metastasis. [1]
A Multicenter Phase II Study shows that plasma levels of GSK1363089 reach ~250 ng/mL at Day 5 but drop to baseline levels by the start of the next cycle. ED50 done for gastric cancer xenograft inhibition is ≥ 0.3 μM (~150 ng/mL). [1]

参考文献

ASCO Annual Meeting. Citation:J Clin Oncol 26: 2008 (May 20 suppl; abstr 5103)

询价