1124329-14-1

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AZ3146/

1124329-14-1

编号ABP000783 化学名称AZ3146/ 英文名称 AZ3146/ MDL: MFCD18384959 分子式C24H32N6O3 分子量452.556 纯度 99 %

化学名称 : AZ3146/

CAS : 1124329-14-1

英文名称: AZ3146/

英文同义词: AZ 3146

溶解度:Unknown

储存条件:at -20℃ 2 years

生物活性

High affinity, selective NOP receptor antagonist (Ki = 8.2 nM). Displays approximately 12.5-, 129- and 1055-fold selectivity over human μ-, κ- and δ-opioid receptors respectively. Exhibits anti-nociceptive effects in acute pain models in vivo. Orally active.

参考文献

Shinkai et al (2000) 4-Aminoquinolines: novel nociceptin antagonists with analgesic activity. J.Med.Chem 43 4667. PMID: 11101358.

Yamada et al (2002) Pharmacological profiles of a novel opioid receptor-like1 (ORL1) receptor antagonist, JTC-801. Br.J.Pharmacol. 135 323. PMID: 11815367.

询价