1086062-66-9
1086062-66-9
编号ABP000103
化学名称GSK2126458
英文名称 GSK2126458
分子式C25H17F2N5O3S
分子量505.496
纯度 >98%
化学名称 : GSK2126458
CAS : 1086062-66-9
英文名称: GSK2126458
英文同义词: 2,4-Difluoro-N-[2-methoxy-5-[4-(4-pyridazinyl)-6-quinolinyl]-3-pyridinyl]benzenesulfonamide
溶解度:DMSO
储存条件:-20°C for 2 years.
生物活性
A Highly Potent Inhibitor of PI3K and the Mammalian Target of Rapamycin,GSK2126458 is also a very potent (PI3K app Ki = 19 pM), reversible,ATP-competitive inhibitor of wild-type PI3K and the ‘hotspot’activating mutants of p110 found in human cancer.GSK2126458 demonstrated good selectivity for the PI3K family of enzymes including the mTORC1 and mTORC2 complexes, when evaluated ina large panel of protein kinases.
参考文献
Discovery of GSK2126458, a Highly Potent Inhibitor of PI3K
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PI3Kalpha inhibitor 1
1235449-52-1
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PI3K-IN-2
1225037-39-7
-
GDC-0941/GDC0941
957054-30-7
-
PIK75/PIK-75 hydrochloride
945619-31-8
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