1072833-77-2

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MLN2238

1072833-77-2

编号ABP000732 化学名称MLN2238 英文名称 MLN2238,MLN 2238,MLN-2238/ MDL: MFCD18251438 分子式C14H19BCl2N2O4 分子量361.031 纯度 >99%

化学名称 : MLN2238

CAS : 1072833-77-2

英文名称: MLN2238,MLN 2238,MLN-2238/

英文同义词: MLN2238

溶解度:Unknown

储存条件:at -20℃ 2 years

生物活性

MLN-2238(1072833-77-2) is a potent reversible and specific β5 site of the 20S proteasome inhibitor with an IC50 value of 3.4 nM. Proteasome activity was significantly inhibited in both blood and tumor following a single dose of MLN2238 administered IV at 14 mg/kg or SC at 4 mg/kg. Proteasome activity was inhibited greater than 50% for up to 8 hrs following the IV dose in both blood and tumor, whereas proteasome activity recovered more quickly following the SC dose. It is active in preclinical models of lymphoma, and that MLN2238(1072833-77-2) has antitumor activity in a model of lymphoma that is refractory to bortezomib treatment

参考文献

[1] http://ash.confex.com/ash/2009/webprogram/Paper20088.html

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