104987-11-3

 主页 / 产品目录 / Others / 104987-11-3
大环哌喃

104987-11-3

编号ABP000474 化学名称大环哌喃 英文名称 FK-506/Tacrolimus MDL: MFCD00869853 分子式C44H69NO12 分子量804.024 纯度 99%

化学名称 : 大环哌喃

CAS : 104987-11-3

英文名称: FK-506/Tacrolimus

英文同义词: TACROLIMUS

溶解度:Soluble in DMSO at 100 mg/ml

储存条件:-20C 2 years

生物活性

Potent calcineurin (protein phosphatase 2B) inhibitor that requires FK 506-binding protein 12 (FKBP12) for activity (IC50 = 3 nM). Inhibits secretion of IL-1, IL-2 (IC50 = 1 nM), IL-3, IL-4, IL-6 (IC50 = 35 nM), GM-CSF, TNFα (IC50 = 10 nM), IFNγ and Myc from activated T-cells in vitro. Exhibits potent immunosuppressive, neuroprotective and anticonvulsant activity in vivo. Analog (ascomycin, Cat. No. 4210) also available.
询价