化学名称 : 大环哌喃
CAS : 104987-11-3
英文名称: FK-506/Tacrolimus
英文同义词: TACROLIMUS
溶解度:Soluble in DMSO at 100 mg/ml
储存条件:-20C 2 years
生物活性
Potent calcineurin (protein phosphatase 2B) inhibitor that requires FK 506-binding protein 12 (FKBP12) for activity (IC50 = 3 nM). Inhibits secretion of IL-1, IL-2 (IC50 = 1 nM), IL-3, IL-4, IL-6 (IC50 = 35 nM), GM-CSF, TNFα (IC50 = 10 nM), IFNγ and Myc from activated T-cells in vitro. Exhibits potent immunosuppressive, neuroprotective and anticonvulsant activity in vivo. Analog (ascomycin, Cat. No. 4210) also available.