1028969-49-4

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1-[1-(1-甲基环辛基)-4-哌啶基]-2-[(3R)-3-哌啶基]-1H-苯并咪唑

1028969-49-4

编号ABP000953 化学名称1-[1-(1-甲基环辛基)-4-哌啶基]-2-[(3R)-3-哌啶基]-1H-苯并咪唑 英文名称 MCOPPB trihydrochloride/ MDL: MFCD18251547 分子式C26H40N4 分子量408.63 纯度 >99%

化学名称 : 1-[1-(1-甲基环辛基)-4-哌啶基]-2-[(3R)-3-哌啶基]-1H-苯并咪唑

CAS : 1028969-49-4

英文名称: MCOPPB trihydrochloride/

英文同义词: MCOPPB

溶解度:Unknown

储存条件:at -20℃ 2 years

生物活性

MK-1775 is a potent and selective Wee1 kinase inhibitor with an IC50 of 5.2 nM. [1]
It abolishes cyclin-dependent kinase 1 (CDC2) activity by phosphorylation of the Tyr15 residue. It abrogates a DNA damage checkpoint (G2-phase), leading to apoptosis in combination with several DNA-damaging agents selectively in p53-deficient tumor cell lines. It is under clinical trial for advanced solid tumors. [2]

参考文献

[1] Dai Y et al. Clin Cancer Res. 2010 Jan 15;16(2):376-83

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