化学名称 : 1-[1-(1-甲基环辛基)-4-哌啶基]-2-[(3R)-3-哌啶基]-1H-苯并咪唑
CAS : 1028969-49-4
英文名称: MCOPPB trihydrochloride/
英文同义词: MCOPPB
溶解度:Unknown
储存条件:at -20℃ 2 years
生物活性
MK-1775 is a potent and selective Wee1 kinase inhibitor with an IC50 of 5.2 nM. [1]
It abolishes cyclin-dependent kinase 1 (CDC2) activity by phosphorylation of the Tyr15 residue. It abrogates a DNA damage checkpoint (G2-phase), leading to apoptosis in combination with several DNA-damaging agents selectively in p53-deficient tumor cell lines. It is under clinical trial for advanced solid tumors. [2]
参考文献