Chemical Name : SB 525334/SB525334
CAS : 356559-20-1
溶解度:DMSO
储存条件:at -20°
生物活性
SB525334 is a selective inhibitor of transforming growth factor-β receptor I (ALK5, TGF-βRI) (IC50=14.3 nM). This agent inhibits TGF-β-induced ALK5 serine/ threonine kinase activity, thereby preventing phosphorylation of the Smad transcription factors and subsequent gene activation.参考文献
[1] Laping NJ. IDrugs 1999;2:907-14