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Cat.No.ABP000080 Chemical NameGDC-0941/GDC0941 MolFormulaC23H27N7O3S2 MolWeight513.636 Purity 99%

Chemical Name : GDC-0941/GDC0941

CAS : 957054-30-7

Synonyms: 2-(1H-Indazol-4-yl)-6-[[4-(methylsulfonyl)-1-piperazinyl]methyl]-4-(4-morpholinyl)thieno[3,2-d]pyrimidine


Storage:at -20℃ 2 years


1.The IC50 values of GDC0941 for the inhibition of phosphorylation of Ser473 on AKT in IGROV-1 cells following 2- or 8-hour exposure were 18 ± 1 and 38 ± 13 nmol/L, respectively.

2.GDC-0941 Causes Sustained Inhibition ofthe Phosphatidylinositide 3-Kinase Pathway in U87MG Glioblastoma Xenografts

3.GDC-0941 was much less potent on mTOR and DNA-PK. Importantly, the activity of GDC-0941 against the panel of human tumor cell lines was generally similar to that of PI-103, suggesting that high potency against mTOR and/or DNA-PK was not essential for the inhibition of cell proliferation. In addition,GDC-0941 potently inhibited growth of activated human endothelial cells, suggesting potential for antiangiogenic activity, as we previously reported for PI-103.


1.Biological properties of potent inhibitors of class I phosphatidylinositide 3-kinases: from PI-103 through PI-540, PI-620 to the oral agent GDC-0941