Chemical Name : JNJ-38877605/JNJ38877605
CAS : 943540-75-8
Synonyms: 6-[Difluoro[6-(1-methyl-1h-pyrazol-4-yl)-1,2,4-triazolo[4,3-b]pyridazin-3-yl]methyl]quinoline
Solubility:DMSO
Storage:at -20℃ 2 years
Biologieal
c-Met inhibitor JNJ-38877605 is an orally bioavailable, small-molecule receptor tyrosine kinase inhibitor with potential antineoplastic activity. It selectively inhibits c-Met (mesenchymal-epithelial transition), a receptor tyrosine kinase (RTK) involved in cancer cell survival and invasiveness, and tumor angiogenesis.
Reference
1. Liu X, Yao W, Newton RC, Scherle PA. Scherle.Targeting the c-MET signaling pathway for cancer therapy. Expert Opin Investig Drugs. 2008 Jul;17(7):997-1011