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Cat.No.ABP000857 Chemical NameBIBF1120,BIBF-1120,Vargatef/ MDL: MFCD11974012 MolFormulaC31H33N5O4 MolWeight539.633 Purity 99%

Chemical Name : BIBF1120,BIBF-1120,Vargatef/

CAS : 928326-83-4

Synonyms: VARGATEF


Storage:-20℃ 2 years


ABT-869 is multi-targeted in that it is a potent inhibitor of all members of the VEGF and PDGF receptor families (e.g., KDR IC50 value of 4 nM), but has much less activity (IC50 values >1 ) against unrelated receptor tyrosine kinases, soluble tyrosine kinases or serine/threonine kinases. The kinase inhibition profile of ABT-869 is evident in cellular assays of RTK phosphorylation (IC50 values of 2, 4 and 7 nM for PDGFR, KDR and CSF-1R, respectively) and VEGF-stimulated proliferation (0.2 nM IC50 for human endothelial cells).


1, ABT-869, a multitargeted receptor tyrosine kinase inhibitor: inhibition of FLT3 phosphorylation and signaling in acute myeloid leukemia. Shankar DB,et al Blood. 2007 Apr 15;109(8):3400-8.

2, Preclinical activity of ABT-869, a multitargeted receptor tyrosine kinase inhibitor. Albert DH, Mol Cancer Ther. 2006 Apr;5(4):995-1006.