Home / Products / Inhibitors / ATM Inhibitor / 925701-49-1


Cat.No.ABP000418 Chemical NameKU-60019/ MolFormulaC30H33N3O5S MolWeight547.665 Purity >99%

Chemical Name : KU-60019/

CAS : 925701-49-1

Synonyms: 2-((2R,6S)-2,6-dimethylmorpholino)-N-(4-(6-morpholino-4-oxo-4H-pyran-2-yl)-9H-thioxanthen-7-yl)acetamide

Storage:at -20℃ 2 years


KU-60019 is 10-fold more effective than KU-55933 at blocking radiation-induced phosphorylation of key ATM targets in human glioma cells. As expected, KU-60019 is a highly effective radiosensitizer of human glioma cells. A-T fibroblasts were not radiosensitized by KU-60019, strongly suggesting that the ATM kinase is specifically targeted. Furthermore, KU-60019 reduced basal S473 AKT phosphorylation, suggesting that the ATM kinase might regulate a protein phosphatase acting on AKT. In line with this finding, the effect of KU-60019 on AKT phosphorylation was countered by low levels of okadaic acid, a phosphatase inhibitor, and A-T cells were impaired in S473 AKT phosphorylation in response to radiation and insulin and unresponsive to KU-60019.


[1] Golding SE et al. Mol Cancer Ther. 2009 Oct; 8(10):2894-902.