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Biologieal

a potent, selective inhibitor of c-Met, a receptor tyrosine kinase that is often deregulated in cancer. AMG 458 was obsd. to bind covalently to liver microsomal proteins from rats and humans in the absence of NADPH. When [14C]AMG 458 was incubated with liver microsomes in the presence of glutathione and N-acetyl cysteine, thioether adducts were detected by radiochromatog

Reference

1. Methods for the treatment of cancer

2. Combinations VEGF(R) inhibitors and hepatocyte growth factor (c-met) inhibitors for the treatment of cancer

3. Development of a high drug load tablet formulation based on assessment of powder manufacturability: moving towards quality by design