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Cat.No.ABP000955 Chemical NameGSK429286A MolFormulaC21H16F4N4O2 MolWeight432.371 Purity >99%

Chemical Name : GSK429286A

CAS : 864082-47-3

Synonyms: N-(6-Fluoro-1H-indazol-5-yl)-2-methyl-6-oxo-4-[4-(trifluoromethyl)phenyl]-1,4,5,6-tetrahydro-3-pyridinecarboxamide

Storage:at -20℃ 2 years


LY2603618 (IC-83) is a highly selective Chk 1 inhibitor with potential antitumor activity. LY2603618 (IC-83) binds to and inhibits the activity of chk1, which may prevent the repair of DNA caused by DNA-damaging agents, thus potentiating the antitumor efficacies of various chemotherapeutic agents. Chk1, an ATP-dependent serine-threonine kinase, is a key component in the DNA replication-monitoring checkpoint system and is activated by double-stranded breaks (DSBs); activated chk1 is overexpressed by a variety of cancer cell types. [1][2]


[1] Dai Y et al. Clin Cancer Res. 2010 Jan 15;16(2):376-83.