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SB 699551/SB-699551


Cat.No.ABP000439 Chemical NameSB 699551/SB-699551 MolFormulaC34H47Cl2N3O MolWeight584.662 Purity >99 %

Chemical Name : SB 699551/SB-699551

CAS : 791789-61-2

Synonyms: N-[2-(Dimethylamino)ethyl]-N-[[4'-[[ (2-phenylethyl)amino]methyl][1,1'-biphenyl]-4-yl]me thyl]cyclopentanepropanamide dihydrochloride

Solubility:Soluble to 25 mM in DMSO and to 10 mM in ethanol

Storage:Store at +4°C


Selective 5-ht5A receptor antagonist


DF Corbett et al. Discovery of a potent and selective 5-ht5A receptor antagonist by high-throughput chemistry. Bioorg. Med. Chem. Letts. 2005, 15, 4014. DR Thomas et al. SB-69951-A (3-cyclopentyl-N-[2-(dimethylamino)ethyl]-N-[(4'-{[(2-phenylethyl)amino]methyl}-4-biphenylyl)methyl]propanamide dihydrochloride), a novel 5-ht5A receptor-selective antagonist, enhances 5-HT neuronal function: evidence for an autoreceptor role for the 5-ht5A receptor in guinea pig brain. Neuropharmacology 2006, 51, 566. DR Thomas. 5-ht5A receptors as a therapeutic target. Pharmacol. Ther. 2006, 111, 707.