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Cat.No.ABP000107 Chemical NameTG100-115 MolFormulaC18H14N6O2 MolWeight346.3428 Purity >99%

Chemical Name : TG100-115

CAS : 677297-51-7

Synonyms: 3,3'-(2,4-diaminopteridine-6,7-diyl)diphenol


Storage:at -20℃ 2 years


TG100-115, inhibited PI3K γ and -δ(IC50 values of 83 and 235 nM, respectively), whereas both PI3Kα and -β were relatively unaffected (IC50 values>1 μM). As a gauge of general specificity, TG100-115 was also assayed against a 133 protein kinase panel, none of which was inhibited at IC50 values <1 μM. [ 2,3] TG100-115 is applied to anti-inflammatory therapy for respiratory diseases such as asthma and chronic obstructive pulmonary disease (COPD). TG100-115 could reduce inflammation and mucin accumulation


[1] http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=25084 [2] John Doukas et al. Proc Natl Acad Sci U S A. 2006 December 26;103(52):19866-71 [3] John Doukas et al. The Journal of Pharmacology and Experimental Therapeutics. 2009 March;328(3):758-765