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Cat.No.ABP000918 Chemical NameAZD-6244(Selumetinib) MolFormulaC17H15BrClFN4O3 MolWeight457.681 Purity 98%

Chemical Name : AZD-6244(Selumetinib)

CAS : 606143-52-6

Synonyms: 5-[(4-Bromo-2-chlorophenyl)amino]-4-fluoro-N-(2-hydroxyethoxy)-1-methyl-1H-benzimidazole-6-carboxamide

Solubility:Soluble to 100 mM in 1.1eq. NaOH and to 10 mM in DMSO

Storage:Store at -20°C


Selectively inhibits HIV reverse transcriptase (RNA-dependent DNA polymerase). Prevents cytotoxicity in SIV-infected C-8166 cells in vitro (IC50 = 1.5 μM). Antiviral agent.


Tsai et al (1995) Prevention of SIV infection in macaques by (R)-9-(2-phosphonylmethoxypropyl)adenine. Science 270 1197. Van Rompay et al (1996) 9-[2-(Phosphonomethoxy)propyl]adenine therapy of established simian immunodeficiency virus infection in infant rhesus macaques. Antimicrob.Agents Chemother. 40 2586. Suo et al (1998) Selective inhibition of HIV-1 reverse transcriptase by an antiviral inhibitor, (R)-9-(2-phosphonylmethoxypropyl)adenine. J.Biol.Chem. 273 27250.