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AZD 5438/AZD-5438


Cat.No.ABP000849 Chemical NameAZD 5438/AZD-5438 MolFormulaC18H21N5O2S MolWeight371.457 Purity >99 %

Chemical Name : AZD 5438/AZD-5438

CAS : 602306-29-6

Synonyms: 4-[2-Methyl-1-(1-methylethyl)-1H-im idazol-5-yl]-N-[4-(methylsulfonyl)phenyl]-2-pyrimi dinamine


Storage:-20℃ 2 years


Nanomolar concentrations of flavopiridol inhibited rhabdoid cell growth (IC50-200nmol/L) , induced G1and G2 arrest, and apoptosis in vitro in a concentration-dependent manner. These effects were correlated with the down-modulation of cyclin D1, up-regulation of p21, and induction of caspase 3/7 activities. Flavopiridol (at 7.5 mg/kg) significantly inhibited the growth of xenografted rhabdoid tumors, and its effect was correlated with the induction of p21 and down-modulation of cyclin D1. [2]
Exposure of HNSCC cells to flavopiridol diminished cdc2 and cdk2 activity and potently inhibited cell proliferation (IC50=43-83 nM), which was concomitant with the appearance of cells with a sub-G1 DNA content. [3]


[1] Lloyd R Kelland . Expert Opinion on Investigational Drugs. 2000 December;9(12):2903-2911

[2] Melissa E. Smith et al. Clin Cancer Res.2008 January 15;14:523-532

[3] Vyomesh Patel et al. The Journal of Clinical Investigation. 1998 November;102(9):1674-1681