58880-19-6

Trichostatin A/TSA

58880-19-6

Cat.No.ABP000141 Chemical NameTrichostatin A/TSA MDL: MFCD03848392 MolFormulaC17H22N2O3 MolWeight302.372 Purity 98% Optical purity 98%

Chemical Name : Trichostatin A/TSA

CAS : 58880-19-6

Synonyms: TRICHOSTATIN A

Solubility:Soluble in MeOH or DMSO

Storage:-20C 2 years

Biologieal

Trichostatin A is a potent, reversible inhibitor of histone deacetylase (HDAC). In human Jurkat T cells, trichostatin A arrests cell cycle progression in G1 and inhibits the activity of the HDAC1 with an IC50 value of 70 nM. Trichostatin A selectively inhibits the removal of acetyl groups from the amino-terminal lysine residues of core histones, which modulates the access of transcription factors to the underlying genomic DNA.

Reference

1 Hoshikawa, Y., Kwon, H.J., Yoshida, M., et al. Trichostatin A induces morphological changes and gelsolin expression by inhibiting histone deacetylase in human carcinoma cell lines. Exp Cell Res 214 189-197 (1994). 2 Taunton, J., Hassig, C.A., Schreiber, S.L. A mammalian histone deacetylase related to the yeast transcriptional regulator Rpd3p. Science 272 408-411 (1996).

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