548472-68-0

Solubility:DMSO

Storage:at -20℃ 2 years

Biologieal

Nutlin-3 is a MDM-2 antagonist with an IC50 of 90 nM. It induces the expression of p53-regulated genes and exhibits potent antiproliferative activity in cells with functional p53, but not in cells with mutated p53. Nutlin-3 also inhibits the growth of human tumor xenografts in nude mice by 90% at a dose of 200 mg/kg.[1][2]

Reference

[1] Secchiero P et al. Neoplasia. 2007 Oct;9(10):853-61.