Chemical Name : Nutlin-3/
CAS : 548472-68-0
Synonyms: NUTLIN-3B
Solubility:DMSO
Storage:at -20℃ 2 years
Biologieal
Nutlin-3 is a MDM-2 antagonist with an IC50 of 90 nM. It induces the expression of p53-regulated genes and exhibits potent antiproliferative activity in cells with functional p53, but not in cells with mutated p53. Nutlin-3 also inhibits the growth of human tumor xenografts in nude mice by 90% at a dose of 200 mg/kg.[1][2]
Reference