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Cat.No.ABP000220 Chemical NameNVP-AEW541/AEW541 MDL: MFCD13184807 MolFormulaC27H29N5O MolWeight439.56 Purity 99%

Chemical Name : NVP-AEW541/AEW541

CAS : 475489-16-8

Synonyms: NVP-AEW541

Solubility:Soluble in DMSO

Storage:at -20℃ 2 years


NVP-AEW541 is a pyrrolo[2,3-d]pyrimidine derivative highly selective against IGF-IR, compared with the insulin receptor and other tyrosine kinases. [1]
In a panel of 10 neuroblastoma cell lines positive for IGF-IR expression, NVP-AEW541 inhibited in vitro proliferation in a submicromolar/micromolar (0.4-6.8) range of concentrations. [1]
NVP-AEW541 inhibits IGF-I-mediated receptor activation and downstream signaling. In addition to growth inhibition, the drug also induced apoptosis in vitro. Oral ad ministration of NVP-AEW541 (50 mg/kg twice daily) inhibited tumor growth of neuroblastoma xenografts in nude mice. [1]
Therapeutic potential of NVP-AEW541 was also analyzed in Ewing’s sarcoma, osteosarcoma, rhabdomyosarcoma, and pancreatic cancer.


[1] Barbara Tanno et al. Clin Cancer Res.2006 November 15;12:6772-6780