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Cediranib (AZD2171)/Recentin


Cat.No.ABP000861 Chemical NameCediranib (AZD2171)/Recentin MolFormulaC25H27FN4O3 MolWeight450.5053 Purity 98%

Chemical Name : Cediranib (AZD2171)/Recentin

CAS : 288383-20-0

Synonyms: 4-(4-Fluoro-2-methylindol-5-yloxy)-6-methoxy-7-[3-(pyrrolidin-1-yl)propoxy]quinazoline

Solubility:Soluble in DMSO

Storage:-20C 2 years


A series of amino acid ester prodrugs of the dual VEGFR-2/FGFR-1 kinase inhibitor 1 (BMS-540215) was prepared in an effort to improve the aqueous solubility and oral bioavailability of the parent compound.The L-alanine prodrug 8 (also known as brivanib alaninate/BMS-582664��an orally available) was selected as a development candidate and is presently in phase II clinical trials.The potency of BMS-540215on the VEGFR-2 and FGFR-1 kinases revealed IC50 values of 25 nM and 148 nM, respectively. BMS-540215 inhibits both VEGF- and basic fibroblast growth factor�Cstimulated human umbilical vascular endothelial cell growth in vitro but does not inhibit tumor cell growth in vitro. In multiple preclinical models of human tumor xenografts, both BMS-582664 and BMS-540215 have shown potent antitumor activity when dosed orally on a once-a-day schedule with complete induction of tumor stasis.


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