2296729-00-3

AMG-510 racemate is a racemic mixture of AMB-510, which is a potent KRAS G12C covalent inhibitor. AMG-510 is a first-in-class, orally bioavailable, and selective KRAS G12C covalent inhibitor. AMG-510 irreversibly inhibits KRAS G12C by locking it in an inactive GDP-bound state. AMG-510 is the first KRAS G12C inhibitor in clinical development and leads to the regression of KRAS G12C tumors.