21102-95-4

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BMY 7378 dihydrochloride

21102-95-4

Cat.No.ABP000464 Chemical NameBMY 7378 dihydrochloride MDL: MFCD00153771 MolFormulaC22H31N3O3.2ClH MolWeight458.427

Chemical Name : BMY 7378 dihydrochloride

CAS : 21102-95-4

溶解度:Soluble to 100 mM in water

生物活性

5-HT1A partial agonist and high affinity α1D adrenoceptor antagonist (Ki values are 2, 800 and 600 nM at cloned rat α1D, rat α1A and hamster α1B receptors respectively). Also available as part of the α1-Adrenoceptor Tocriset™.

参考文献

Sharp et al (1990) Further investigation of the in vivo pharmacological properties of the putative 5-HT1A antagonist, BMY 7378. Eur.J.Pharmacol. 176 331. Gruel and Glaser (1992) The putative 5-HT1A receptor antagonists NAN-190 and BMY 7378 are partial agonists in the rat dorsal raphe nucleus in vitro. Eur.J.Pharmacol. 211 211. Piascik et al (1995) The specific contribution of the novel alpha-1D adrenoceptor to the contraction of vascular smooth muscle. J.Pharmacol.Exp.Ther. 275 1583. Yang and Endoh (1997) Pharmacological evidence for a1D-adrenoceptors in the rabbit ventricular myocardium: analysis with BMY 7378. Br.J.Pharmacol. 122 1541.

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