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RS 127445 hydrochloride


Cat.No.ABP000805 Chemical NameRS 127445 hydrochloride MDL: MFCD20270616 MolFormulaC17H16FN3 MolWeight281.332 Purity >98 %

Chemical Name : RS 127445 hydrochloride

CAS : 199864-87-4

Synonyms: RS-127445

Solubility:Soluble to 30 mM in ethanol and to 100 mM in DMSO and to 20 mM in Tocrisolve (Cat.No.1684)

Storage:Store at +4°C


Nanomolar affinity cannabinoid receptor agonist (Ki values are 62.3 and 3.3 nM at the human cloned CB1 and CB2 receptors respectively). Also available as part of the Cannabinoid Receptor Agonist Tocriset™. S-enantiomer WIN 55,212-3 mesylate (Cat. No. 2327) also available


D'Ambra et al (1992) Conformationally restrained analogues of pravadoline: nanomolar potent, enantioselective, (aminoalkyl)indole agonists of the cannabinoid receptor. J.Med.Chem. 35 124. PMID: 1732519.

Felder et al (1995) Comparison of the pharmacology and signal transduction of the human cannabinoid CB1 and CB2 receptors. Mol.Pharmacol. 48 443. PMID: 7565624.

Griffin et al (1998) Evaluation of cannabinoid receptor agonists and antagonists using the guanosine-5'-O-(3-[35S]thio)-triphosphate binding assay in rat cerebellar membranes. J.Pharmacol.Exp.Ther. 285 553. PMID: 9580597.