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U-95666E(Sumanirole maleate)/U95666E


Cat.No.ABP000216 Chemical NameU-95666E(Sumanirole maleate)/U95666E MDL: MFCD09832637 MolFormulaC11H13N3O.C4H4O4 MolWeight319.315 Purity >99%

Chemical Name : U-95666E(Sumanirole maleate)/U95666E

CAS : 179386-44-8


Storage:at -20℃ 2 years


Sumanirole maleate is a highly selective D2 receptor full agonist with an ED50 of about 46 nM. It has greater than 200-fold selectivity for the D2 receptor subtype versus the other dopamine receptor subtypes in radioligand binding assays. In cell-based assays, sumanirole is a fully efficacious agonist, with EC50 values between 17 and 75 nM. In animals, sumanirole elicits many physiological responses attributed to D2-like receptor function. In rats, sumanirole is a full agonist for elevation of striatal acetylcholine levels (ED50 = 12.1 μmol/kg i.p.). Sumanirole s.c. dose dependently decreased plasma prolactin levels and depressed dopamine neuron firing rates in the substantia nigra pars compacta with an ED50 of 2.3 μmol/kg i.v.


[1] http://en.wikipedia.org/wiki/Sumanirole