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Perifosine/D21266 /D-21266


Cat.No.ABP000409 Chemical NamePerifosine/D21266 /D-21266 MDL: MFCD00927554 MolFormulaC25H52NO4P MolWeight461.663 Purity 99%

Chemical Name : Perifosine/D21266 /D-21266

CAS : 157716-52-4


Solubility:Soluble in water at 10mg/ml

Storage:-20C 2 years


Alkylphospholipids are a class of antineoplastic compounds that display potent antiproliferative activity in several in vitro and in vivo human tumor models. Perifosine(D 21266 ) is an alkylphospholipid that induces apoptotic cell death in a variety of tumor cell lines. Apoptosis is induced in a time- and dose-dependent manner in U937 and Jurkat T human leukemia cell lines but not in normal vascular endothelial cells. Perifosine(D 21266 ) causes inhibition of PC-3 prostate carcinoma cell growth (growth inhibition (GI50) = 5µM at 24h) and is associated with rapidly decreased Akt activation. In addition, perifosine induces p21WAF1 expression in squamous carcinoma cells through a p53-independent pathway, leading to loss in cyclin-dependent kinase activity and cell cycle arrest.


1 Ruiter, G.A., Zerp, S.F., Bartelink, H., et al. Alkyl-lysophospholipids activate the SAPK/JNK pathway and enhance radiation-induced apoptosis. Cancer Res 59 2457-2463 (1999).

2 Kondapaka, S.B., Singh, S.S., Dasmahapatra, G.P., et al. Perifosine, a novel alkylphospholipid, inhibits protein kinase B activation. Molecular Cancer Therapeutics 2 1093-1103 (2003).