Chemical Name : Abiraterone(CB-7598)/CB7598
CAS : 154229-19-3
Storage:-20C 2 years
ABIRATERONE(CB-7598), a steroidal cytochrome P450 17alpha-hydroxylase-17,20-lyase inhibitor (CYP17), is currently undergoing phase II clinical trials as a potential drug for the treatment of androgen-dependent prostate cancer.In preclinical studies, ABIRATERONE(CB-7598) has demonstrated the ability to selectively inhibit the target enzyme (IC50 4 nM for hydroxylase), resulting in inhibition of testosterone production in both the adrenals and the testes. Clinical studies demonstrated that CYP17 blockade by ABIRATERONE(CB-7598) acetate is safe and has significant antitumor activity in CRPC (castration-resistant prostate cancer).In 2008, enrolment had commenced into a Phase I/II trial of CB7630 (ABIRATERONE acetate) in patients with advanced breast cancer.
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