Chemical Name : PD169316
CAS : 152121-53-4
Synonyms: Pyridine, 4-[4-(4-fluorophenyl)-2-(4-nitrophenyl)-1H-imidazol-5-yl]-
Storage:at -20℃ 2 years
Potent, cell-permeable and selective inhibitor of p38 MAP kinase (MAPK); it blocks apoptosis induced by trophic factor withdrawal in non-neuronal and neuronal cell lines.
DJ. Samuvel et al. A Role for p38 Mitogen-Activated Protein Kinase in the Regulation of the Serotonin Transporter: Evidence for Distinct Cellular Mechanisms Involved in Transporter Surface Expression. J. Neuroscience, 2005, 25(1), 29-41. Y Fu et al. The p38 MAPK inhibitor, PD169316, inhibits transforming growth factor beta-induced Smad signaling in human ovarian cancer cells. Biochem Biophys Res Commun. 2003, 310(2), 391-7. JL Kummer et al. Apoptosis induced by withdrawal of trophic factors is mediated by p38 mitogen-activated protein kinase. J Biol Chem 1997, 272(33), 20490-20494. R Nath et al. Inhibition of p38 kinase mimics survival signal-linked protection against apoptosis in rat cerebellar granule neurons. Cell. Mol. Biol. Lett. 2001, 6, 173-184.