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Cat.No.ABP000960 Chemical NameLY2608204/ MDL: MFCD21609257 MolFormulaC28H37N3O3S3 MolWeight559.816 Purity >99%

Chemical Name : LY2608204/

CAS : 1234703-40-2

Synonyms: LY2608204

Storage:at -20℃ 2 years


CX-5461 is a potent small-molecule rRNA synthesis inhibitor with an IC50 of 0.11 μM. Deregulated ribosomal RNA synthesis is associated with uncontrolled cancer cell proliferation. RNA Polymerase I (Pol I), the multi-protein complex that synthesizes rRNA, is activated widely in cancer. Thus, selective inhibitors of RNA PolI may offer a general therapeutic strategy to block cancer cell proliferation. CX-5461 selectively blocks RNA PolI transcription,PIC assembly and SL1-rDNA interaction. CX-5461 indicates potent antiproliferative activity in cancer cells and induces autophagy incancer cells. CX-5461 shows potent antitumor activity in A375 and MiaPaca xenografts. [1][2]


[1] Drygin D et al. Cancer Res. 2011 Feb 15;71(4):1418-30.