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Cat.No.ABP000112 Chemical NameCAY10505 MolFormulaC14H8FNO3S MolWeight289.282 Purity >99%

Chemical Name : CAY10505

CAS : 1218777-13-9

Synonyms: (5E)-5-{[5-(4-Fluorophenyl)-2-furyl]methylene}-1,3-thiazolidine-2,4-dione

Storage:at -20℃ 2 years


CAY10505 is a potent PI3Kγ inhibitor with an IC50 of 30 nM. Phosphoinositide 3-kinase γ (PI3Kγ) is expressed primarily in hematopoietic cells and plays several important roles in immunity. CAY10505  also prevents other α, β, and δ isoforms with IC50 of 0.94, 20, and 20 μM, respectively. CAY10505  significantly inhibits only the unrelated casein kinase 2 (CK2, IC50 = 20 nM). CAY10505  also suppress the phosphorylation of the PI3K substrate PKB/Akt in murine macrophages (IC50 = 228 nM). Oral administration of CAY10505  decreases neutrophil recruitment in mice to an extent that is comparable to that observed in PI3Kγ-deficient mice. [1]


[1] Pomel V et al. J Med Chem. 2006 Jun 29;49(13):3857-71.