1218777-13-9

Storage:at -20℃ 2 years

Biologieal

CAY10505 is a potent PI3Kγ inhibitor with an IC50 of 30 nM. Phosphoinositide 3-kinase γ (PI3Kγ) is expressed primarily in hematopoietic cells and plays several important roles in immunity. CAY10505  also prevents other α, β, and δ isoforms with IC50 of 0.94, 20, and 20 μM, respectively. CAY10505  significantly inhibits only the unrelated casein kinase 2 (CK2, IC50 = 20 nM). CAY10505  also suppress the phosphorylation of the PI3K substrate PKB/Akt in murine macrophages (IC50 = 228 nM). Oral administration of CAY10505  decreases neutrophil recruitment in mice to an extent that is comparable to that observed in PI3Kγ-deficient mice. ^[1]

Reference

[1] Pomel V et al. J Med Chem. 2006 Jun 29;49(13):3857-71.