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Cat.No.ABP000925 Chemical NameBMS-777607/BMS777607/ MolFormulaC25H19ClF2N4O4 MolWeight512.893 Purity >99%

Chemical Name : BMS-777607/BMS777607/

CAS : 1196681-44-3

Synonyms: N-[4-[(2-Amino-3-chloro-4-pyridinyl)oxy]-3-fluorophenyl]-4-ethoxy-1-(4-fluorophenyl)-1,2-dihydro-2-oxo-3-pyridinecarboxamide

Storage:at -20℃ 2 years


PD318088(PD-318088) is a non-ATP competitive allosteric MEK1/2 inhibitor. MEK1 and MEK2 are closely related, dual-specificity tyrosine/threonine protein kinases found in the Ras/Raf/MEK/ERK mitogen-activated protein kinase (MAPK) signaling pathway.The MEK1 inhibitor PD318088 binds simultaneously with ATP in a region of the kinase active site that is adjacent to the ATP-binding site. Birb796 binding to p38  extends into the ATP site, but also accesses this back pocket, partly overlapping the region where PD318088 binds in MEK1


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[2] Sebolt-Leopold JS et al. Nature. 2006 May 25;441(7092):457-62.