1196681-44-3

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Biologieal

PD318088(PD-318088) is a non-ATP competitive allosteric MEK1/2 inhibitor. MEK1 and MEK2 are closely related, dual-specificity tyrosine/threonine protein kinases found in the Ras/Raf/MEK/ERK mitogen-activated protein kinase (MAPK) signaling pathway.The MEK1 inhibitor PD318088 binds simultaneously with ATP in a region of the kinase active site that is adjacent to the ATP-binding site. Birb796 binding to p38  extends into the ATP site, but also accesses this back pocket, partly overlapping the region where PD318088 binds in MEK1

Reference

[1] Ohren JF et al. Nat Struct Mol Biol. 2004 Dec;11(12):1192-7.
[2] Sebolt-Leopold JS et al. Nature. 2006 May 25;441(7092):457-62.