364782-34-3

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Cinacalcet hydrochloride/AMG073/Mimpara, Cinacalcet hydrochloride, Sensipar/

364782-34-3

Cat.No.ABP000405 Chemical NameCinacalcet hydrochloride/AMG073/Mimpara, Cinacalcet hydrochloride, Sensipar/ MolFormulaC22H23ClF3N MolWeight393.873 Purity >99%

Chemical Name : Cinacalcet hydrochloride/AMG073/Mimpara, Cinacalcet hydrochloride, Sensipar/

CAS : 364782-34-3

Synonyms: N-[(1R)-1-naphthalen-1-ylethyl]-3-[3-(trifluoromethyl)phenyl]propan-1-amine hydrochloride

Solubility:DMSO

Storage:at -20℃ 2 years

Biologieal

AMG-073(Cinacalcet hydrochloride) represents a new class of compounds for the treatment of hyperparathyroidism known as calcimimetics, which reduce parathyroid hormone (PTH) synthesis and secretion by increasing the sensitivity of the parathyroid calcium-sensing receptor (CaR) to extracellular calcium. The current study evaluates the efficacy and safety of AMG 073 when added to conventional treatment of secondary hyperparathyroidism in end-stage renal disease (ESRD).

Reference

[1] Quarles LD et al. J Am Soc Nephrol. 2003 Mar;14(3):575-83.

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